Knox county is in the Eastern Coal Field region of Kentucky. The elevation in the county ranges from 890 to 2322 feet above sea level.
In 2010 the county population was 31,883 in a land area of 386.30 square miles, an average of 82.5 people per square mile.
The equine population was 600 in the 2012 Kentucky Equine Survey.
Knox county was named for General Henry Knox, who served in the Continental Army and was the first United States Secretary of War.