Carlisle, the seat of Nicholas county, was established in 1816 and probably named for Carlisle, Pennsylvania. It replaced Ellisville as county seat in 1816. Carlisle was incorporated in 1880. The first post office opened in 1817. The population in 2010 was 2,010.
The Nicholas County Courthouse in Carlisle
- Carlisle-Nicholas County Chamber of Commerce
- Carlisle-Nicholas County Tourism
- Nicholas County Fiscal Court
- Nicholas County Public Library
- Nicholas County Schools