Keene is a Jessamine county town at the junction of KY 169 and KY 1267. It was founded in 1794 and named North Liberty in 1813. Keene was incorporated in 1844. In 1830 the post office opened as Keene.
Keene was once a popular resort because of a nearby spring and supported a hotel and rail line. Many people from Lexington moved to Keene during the cholera epidemics of 1833 and 1849. The Keene Springs Hotel, which operated into the twentieth century, is on the National Register of Historic Places.