Carlisle county is in the Jackson Purchase region of Kentucky. The elevation in the county ranges from 283 to 550 feet above sea level.
In 2010 the county population was 5,104 in a land area of 189.43 square miles, an average of 26.9 people per square mile.
The equine population was 300 in the 2012 Kentucky Equine Survey.
Carlisle county was named to honor John G. Carlisle, who served as Speaker of the United States House of Representatives and Secretary of the Treasury.