Henderson county is in the Western Coal Field region of Kentucky. The elevation in the county ranges from 331 to 588 feet above sea level.
In 2010 the county population was 46,250 in a land area of 436.67 square miles, an average of 105.9 people per square mile.
The equine population was 1,300 in the 2012 Kentucky Equine Survey.
Henderson county was named to honor Richard Henderson, founder of the Transylvania Company.