Tyrone is an Anderson county commmunity along the Kentucky River about three miles east of Lawrenceburg. The site was first known as Streamville. In 1869 James Ripy built a distillery, or expanded an older distillery, which he named Tyrone for his family's home county in Ireland. The population of the town reached nearly 1,000 before Prohibition closed the distillery. The distillery later reopened – it now produces Wild Turkey bourbon. It has had several names and has passed through several owners through the years. It has been owned by the Campari Group since 2009.
A post office opened as Coke (named for its postmaster) in 1882, but it was renamed Tyrone in 1893. It closed in 1943.
In 1888 the Southern Railway built Young's High Bridge over the Kentucky River at Tyrone. It no longer carries rail traffic and is being redeveloped for recreational uses.
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